Shivam's paper is published in Computational and Structural Biotechnology Journal.
- complex analysis
- Sep 18
- 1 min read
Shivam's paper titled "konnect2prot 2.0: Integrating advanced analytical tools for deeper understanding of protein properties in a functional protein-protein interaction network" is published in Computational and Structural Biotechnology Journal.
Proteins work in coordination to catalyze and regulate all biological activities and drive cellular functions. The collective behaviour of proteins is studied through protein-protein interaction (PPI) networks, which provide a system-level understanding of their regulatory behaviour. konnect2prot (k2p) is a web application that generates a context-specific directional PPI network from a list of proteins as input. It identifies influential spreaders in the generated network and detects their biological and topological importance. Here, we report the features added to k2p since its first release. Building on the foundation of its predecessor, k2p 2.0 now integrates differential gene expression analysis, thereby bridging the gap between gene-level regulation and protein-level activity, providing a holistic view of how transcriptional changes fuel cellular behaviour. konnect2prot 2.0 is freely accessible at: https://konnect2prot_v2.thsti.in.



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