Poulomi's paper is published in Applied Mathematical Modelling Journal.

Poulomi’s paper titled “A minimal mathematical model to study B-cell receptor signalling mediated calcium dynamics” was published in Applied Mathematical Modelling. B-cell receptor (BCR) signalling is a central regulator of cytosolic calcium (Ca2+) in B cells, governing distinct cell fates, including survival and apoptosis. Dysregulation of BCR signalling and Ca2+ homeostasis plays a crucial role in B-cell lymphoma.  We developed a minimal mathematical model to understand the role of BCR signalling in inducing pro- and anti-apoptotic Ca2+ dynamics in B-cell lymphoma conditions. Using our model, we observed Ca2+ oscillations in B cells and examined how varying model parameters affect Ca2+ dynamics. We proposed restoration strategies to induce cellular apoptosis through sustained high Ca2+ levels in B-cell lymphoma.