Jayendrajyoti's paper is published in J. R. Soc. Interface
Excited to share our latest research publication!
Our work, “Host strategies that restore switch for apoptosis during Mycobacterium tuberculosis infection,” has been published in the Journal of the Royal Society Interface.
Imagine a light switch with two stable states: ON and OFF. A small change in input may not immediately change its state; it can remain in either state until conditions are sufficient to switch it. Biological systems can behave similarly, a phenomenon known as bistability. In apoptosis, this means a macrophage can exist in either a survival state or a programmed cell-death state. Mtb can manipulate this switch to favour its survival inside macrophages. In our study, we developed a mathematical model to understand how Mtb disrupts this switch and explored potential restoration strategies to reinstate bistability and promote host-cell apoptosis.
#Tuberculosis #MycobacteriumTuberculosis #SystemsBiology #MathematicalModelling #Bistability #Apoptosis #HostDirectedTherapy #ComputationalBiology #Biomathematics #HostPathogenInteractions
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